What is this study about?
About the Study
This study is testing a new medication called BRP-180 to see if it can help people with narcolepsy. Narcolepsy is a sleep disorder that causes excessive daytime sleepiness and sudden muscle weakness (called cataplexy).
Study Goal
The goal of the study is to find out if BRP-180 can help people stay awake during the day and reduce symptoms like cataplexy.
What will happen in the study?
Study Length
About 20 weeks (5 months), including screening, treatment, and follow-up.
Treatment Period
8 weeks of taking either BRP-180 or a placebo (a pill with no active medication).
Follow-Up
4 weeks after the treatment ends to check how you’re doing.
What will I do?
01
Take one pill every morning for 8 weeks.
02
Keep a daily diary to track your sleepiness, naps, and any cataplexy episodes.
03
Complete some questionnaires about how you’re feeling and how the treatment is working.
04
Have a few visits to the study site for check-ups, including a special test called the Maintenance of Wakefulness Test (MWT) to measure how awake you can stay.
Who can join?
You may be able to join if:
You are between 18 and 65 years old.
You have been diagnosed with narcolepsy.
You experience excessive daytime sleepiness or have 3-7 cataplexy episodes per week.
You are willing to stop taking your current narcolepsy medications during the study.
You cannot join if:
You have other sleep disorders or serious medical conditions.
You have had severe allergic reactions to Bupropion (a medication similar to BRP-180).
You use certain medications that could interfere with the study.
What are the benefits of joining?
Advance Research
You may help researchers find a new treatment for narcolepsy.
Medical Monitoring
You’ll receive close medical monitoring from a team of healthcare professionals.
New Treatment Access
You’ll have access to a potential new treatment for narcolepsy.
What are the risks?
Serious Side Effects
Small risk of seizures or changes in blood pressure
Common Side Effects
Headache, dry mouth, nausea, trouble sleeping
Safety Monitoring
The study team will monitor you closely to keep you safe
Like any medication, BRP-180 may cause side effects. Common side effects of Bupropion (a similar medication) include headache, dry mouth, nausea, and trouble sleeping. There is a small risk of more serious side effects, such as seizures or changes in blood pressure. The study team will monitor you closely to keep you safe.
How do I join?
01
Review Study Information
Make sure you understand what the study involves
02
Contact the Study Team
Reach out via email or phone
03
Complete Screening
Determine if you’re eligible to participate
04
Begin Participation
Start the clinical trial process
If you’re interested in joining the study or want more information, please contact the study team:
Email: info@actionsmo.com
Book a call with one of our Study Team
Where is the study happening?
5-10
Clinics
Study sites across Australia
1
Region
Australia
This study is being conducted at 5-10 clinics across Australia. If you’re interested, we can help you find a study site near you.
Your privacy is important
Confidentiality
All your personal information will be kept confidential
Limited Access
Only the study team will have access to your data
Research Use
Data will be used only for research purposes
Have more questions?
How do I download the full study information?
How can I contact the study team directly?
Click on Email Us to send a message to our study team. or Book a time for one of our study team to call you
How can I apply and check my eligibility?
Voluntary Participation
Informed Decision
Understand all aspects before joining
Voluntary Consent
Choose to participate freely
Freedom to Withdraw
Leave the study at any time
Note: This is a research study, and participation is voluntary. You can leave the study at any time without affecting your regular medical care.